Original Article

Evaluation of the frequency and severity of complications of COVID-19 vaccines in the medical staff

Abstract

Background: There are few reports related to the possible side effects of injected vaccines, and evaluating the frequency and severity of the complications of COVID-19 vaccines can increase the knowledge, safety and importance of vaccines and reduce mistrust towards them. Therefore, we assessed the frequency and severity of the complications of COVID-19 vaccines in the medical staff of Khatam Al-Anbia and Ali Ibn Abi Talib hospitals in Zahedan.

Methods: In this cross-sectional study, 200 medical staff working in two hospitals, Khatam Al Anbia and Ali Bin Abitalib Zahedan were studied. The frequency of side effects after COVID-19 vaccination was recorded in the questionnaire.

Results: The distribution of the frequency of the type of vaccine received in the studied treatment group is equal to 83 people (41.5%) AstraZeneca vaccine, 82 people (41%) Sinopharm vaccine, 22 people (11%) Sputnik vaccine and 13 people (6.5 %) had received Barekat vaccine. The frequency distribution of side effects in the first dose and the second dose after receiving the COVID-19 vaccine was equal to 135 people (67.5%) and 96 people (48%), respectively. Distribution of the percentage of the type of side effect that occurred after receiving the first dose of COVID-19, according to fever (80.7%), headache (46.7%), weakness (40%), disorder Sleep (33.3%), myalgia (n19.2%), sweating (10.3%), dizziness (9.6%), tachycardia (18.8%), sore throat (6.7%), chest pain (5.2%), arthralgia (5.2%), rhinorrhea (3.7%), diarrhea (2.9%) and loss of appetite (2.9%).

Conclusions: It can be stated that the COVID-19 vaccine did not show severe side effects and with timely management and supportive treatment and control of side effects, patients were encouraged to get vaccinated and as a result, the collective immunity level of the society improved.

1. Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.
2. Yang S, Shi Y, Lu H, Xu J, Li F, Qian Z, et al. Clinical and CT features of early stage patients with COVID-19: a retrospective analysis of imported cases in Shanghai, China. European Respiratory Journal. 2020;55(4):2000407.
3. Xie J, Tong Z, Guan X, Du B, Qiu H. Clinical characteristics of patients who died of coronavirus disease 2019 in China. JAMA network open. 2020;3(4):e205619-e.
4. Kim ES, Chin BS, Kang CK, Kim NJ, Kang YM, Choi J-P, et al. Clinical course and outcomes of patients with severe acute respiratory syndrome coronavirus 2 infection: a preliminary report of the first 28 patients from the Korean cohort study on COVID-19. Journal of Korean medical science. 2020;35(13).
5. Tu H, Tu S, Gao S, Shao A, Sheng J. Current epidemiological and clinical features of COVID-19; a global perspective from China. The COVID-19 reader. 2020:53-72.
6. Bok K, Sitar S, Graham BS, Mascola JR. Accelerated COVID-19 vaccine development: milestones, lessons, and prospects. Immunity. 2021;54(8):1636-51.
7. Kashte S, Gulbake A, El-Amin Iii SF, Gupta A. COVID-19 vaccines: rapid development, implications, challenges and future prospects. Hum Cell. 2021;34(3):711-33.
8. Trougakos IP, Terpos E, Alexopoulos H, Politou M, Paraskevis D, Scorilas A, et al. Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis. Trends Mol Med. 2022;28(7):542-54.
9. Burki TK. The Russian vaccine for COVID-19. The Lancet Respiratory Medicine. 2020;8(11):e85-e6.
10. Dawood AA. The effects of the Russian vaccine (Sputnik V) on the volunteers. Apollo Medicine. 2021;18(Suppl 1):52-3.
11. Komissarov AA, Dolzhikova IV, Efimov GA, Logunov DY, Mityaeva O, Molodtsov IA, et al. Boosting of the SARS-coV-2–specific immune response after vaccination with single-dose sputnik light vaccine. The Journal of Immunology. 2022;208(5):1139-45.
12. Bellinato F, Maurelli M, Gisondi P, Girolomoni G. Cutaneous adverse reactions associated with SARS-CoV-2 vaccines. Journal of clinical medicine. 2021;10(22):5344.
13. Bardenheier BH, Gravenstein S, Blackman C, Gutman R, Sarkar IN, Feifer RA, et al. Adverse events following mRNA SARS-CoV-2 vaccination among US nursing home residents. Vaccine. 2021;39(29):3844-51.
14. Borroni E, Consonni D, Cugno M, Lombardi A, Mangioni D, Bono P, et al. Side effects among healthcare workers from a large Milan university hospital after second dose of BNT162b2 mRNA COVID-19 vaccine. Med Lav. 2021;112(6):477-85.
15. Mohamed MS, Mohamed AO, Alenazy R, Khan YH, Idriss MT, Alhudaib NAA, et al. A First Report on Side-Effects of COVID-19 Vaccines among General Population in Sudan: A Cross-Sectional Analysis. Vaccines. 2023;11(2).
16. Cascini F, Pantovic A, Al-Ajlouni YA, Failla G, Puleo V, Melnyk A, et al. Social media and attitudes towards a COVID-19 vaccination: A systematic review of the literature. EClinicalMedicine. 2022;48:101454.
17. Paczkowska A, Hoffmann K, Michalak M, Hans-Wytrychowska A, Bryl W, Kopciuch D, et al. Safety Profile of COVID-19 Vaccines among Healthcare Workers in Poland. Vaccines. 2022;10(3).
18. Zare H, Rezapour H, Mahmoodzadeh S, Fereidouni M. Prevalence of COVID-19 vaccines (Sputnik V, AZD-1222, and Covaxin) side effects among healthcare workers in Birjand city, Iran. International immunopharmacology. 2021;101(Pt B):108351.
19. Lee DS, Kim JW, Lee KL, Jung YJ, Kang HW. Adverse events following COVID-19 vaccination in South Korea between February 28 and August 21, 2021: A nationwide observational study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022;118:173-82.
20. Hatmal MmM, Al-Hatamleh MAI, Olaimat AN, Hatmal M, Alhaj-Qasem DM, Olaimat TM, et al. Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects. Vaccines. 2021;9(6):556.
Files
IssueVol 7, No 3 (2024) QRcode
SectionOriginal Article
DOI https://doi.org/10.18502/igj.v7i3.17884
Keywords
COVID-19 Complications Immunity Vaccination
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Miri A, Soleimani G, Masoumpoor A, Sarhadi S. Evaluation of the frequency and severity of complications of COVID-19 vaccines in the medical staff. Immunol Genet J. 2024;7(3):188-192.