Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 7 3 2024 09 22 188 192 Aghil Miri Department of Pediatric Medicine, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Gholamreza Soleimani Children and Adolescents Health Research Center, Research Institute of Cellular and Molecular Science in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran Ali Masoumpoor Department of Pediatric Medicine, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Saeedeh Sarhadi Department of Community Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. 2025 02 12 2025 02 12 Background: There are few reports related to the possible side effects of injected vaccines, and evaluating the frequency and severity of the complications of COVID-19 vaccines can increase the knowledge, safety and importance of vaccines and reduce mistrust towards them. Therefore, we assessed the frequency and severity of the complications of COVID-19 vaccines in the medical staff of Khatam Al-Anbia and Ali Ibn Abi Talib hospitals in Zahedan. Methods: In this cross-sectional study, 200 medical staff working in two hospitals, Khatam Al Anbia and Ali Bin Abitalib Zahedan were studied. The frequency of side effects after COVID-19 vaccination was recorded in the questionnaire. Results: The distribution of the frequency of the type of vaccine received in the studied treatment group is equal to 83 people (41.5%) AstraZeneca vaccine, 82 people (41%) Sinopharm vaccine, 22 people (11%) Sputnik vaccine and 13 people (6.5 %) had received Barekat vaccine. The frequency distribution of side effects in the first dose and the second dose after receiving the COVID-19 vaccine was equal to 135 people (67.5%) and 96 people (48%), respectively. Distribution of the percentage of the type of side effect that occurred after receiving the first dose of COVID-19, according to fever (80.7%), headache (46.7%), weakness (40%), disorder Sleep (33.3%), myalgia (n19.2%), sweating (10.3%), dizziness (9.6%), tachycardia (18.8%), sore throat (6.7%), chest pain (5.2%), arthralgia (5.2%), rhinorrhea (3.7%), diarrhea (2.9%) and loss of appetite (2.9%). Conclusions: It can be stated that the COVID-19 vaccine did not show severe side effects and with timely management and supportive treatment and control of side effects, patients were encouraged to get vaccinated and as a result, the collective immunity level of the society improved. https://igj.tums.ac.ir/index.php/igj/article/view/175 https://igj.tums.ac.ir/index.php/igj/article/download/175/155