Evaluating the impact of different genetic variants on the prognosis of patient with COVID-19
-
Soroush Najdaghi
,
Farzaneh Darbeheshti
,
Sepideh Razi
,
Mahsa Keshavarz-Fathi
,
Simin Ghaemkhah
,
Vahid Shaygannejad
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan (China). It soon became widespread so that the World Health Organization (WHO) declared the outbreak of COVID-19 as a pandemic crisis. This disease has caused significant morbidity and mortality in the world. Clinical studies reported that there is a significant correlation between genders, immunogenetic variants, serum levels of some circulating factors, blood groups, and different races with severity and mortality of COVID-19 patients. Hence, some studies have investigated the role of individual genetic background in the susceptibility and vulnerability to COVID-19 infection. It is proposed that host genetic polymorphisms affect the onset and progression of COVID-19 infection and could dramatically impact the virus life cycle. This paper aims to review the state-of-the-art researches on the roles of genetic variants in host cell membrane proteins and blood circulation factors in the prognosis of patients with COVID-19.
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| Files | ||
| Issue | Vol 5, No 3 (2022) | |
| Section | Review Article | |
| DOI | https://doi.org/10.18502/igj.v5i3.16037 | |
| Keywords | ||
| COVID-19 SARS-CoV-2 Polymorphism Prognosis Host Genetic Factors Susceptibility | ||
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How to Cite
1.
Najdaghi S, Darbeheshti F, Razi S, Keshavarz-Fathi M, Ghaemkhah S, Shaygannejad V. Evaluating the impact of different genetic variants on the prognosis of patient with COVID-19. Immunol Genet J. 2022;5(3):103-118.
