Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 5 3 2022 09 22 103 118 Soroush Najdaghi Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Farzaneh Darbeheshti Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Sepideh Razi Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran Mahsa Keshavarz-Fathi School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Simin Ghaemkhah Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Vahid Shaygannejad Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 2023 01 04 2023 02 28 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan (China). It soon became widespread so that the World Health Organization (WHO) declared the outbreak of COVID-19 as a pandemic crisis. This disease has caused significant morbidity and mortality in the world. Clinical studies reported that there is a significant correlation between genders, immunogenetic variants, serum levels of some circulating factors, blood groups, and different races with severity and mortality of COVID-19 patients. Hence, some studies have investigated the role of individual genetic background in the susceptibility and vulnerability to COVID-19 infection. It is proposed that host genetic polymorphisms affect the onset and progression of COVID-19 infection and could dramatically impact the virus life cycle. This paper aims to review the state-of-the-art researches on the roles of genetic variants in host cell membrane proteins and blood circulation factors in the prognosis of patients with COVID-19. https://igj.tums.ac.ir/index.php/igj/article/view/118 https://igj.tums.ac.ir/index.php/igj/article/download/118/105