Immunology and Genetics Journal is the official journal of the Research Center For Immunodeficiencies, Tehran University of Medical Sciences. The journal is a Quarterly peer-reviewed, Open Access journal, publishing high quality scientific (basic and translational) and clinical-epidemiological papers on a wide range of pediatric and adult genetics and immunological topics, including Clinical Genetics, Clinical Immunology, Infection and Immunity, Autoimmunity, Immunobiology, Immunogenetics, Immunohematology, Immunopathology, Transplantation, and Cancer immunology.
This journal, which is supported by Universal Scientific Education and Research Network, publishes original articles, review articles, short communications, letters to the editors, clinical trials, systematic review and meta-analysis, and case reports. The quality and originality of the research are the most important criteria for acceptance. Immunology and Genetics Journal attempts to ensure a quick publication of all manuscripts while preserving the highest quality of contents.
All submitted manuscripts are checked for similarity through a trustworthy software named iThenticate to be assured about its originality.
- Country of Publication: Iran
- Owner: Tehran University of Medical Sciences
- Publisher: Tehran University of Medical Sciences
- Format: Electronic Only
- E-ISSN: 2645-4831
- Acceptance Rate: 30%
- Frequency: Quarterly
- Language: English
- Scope: High quality scientific (basic and translational) and clinical-epidemiological papers on a wide range of pediatrics and adult immunological and genetical disorders including topics such as Clinical immunology, Infection immunology, Immunobiology, Immunogenetics, Immunohematology, Immunopathology, Transplantation immunology, Tumor immunology.
- Article Processing Charges: Free of charge
- Type of Journal: Scientific - research
- Open Access: All papers are freely available
- Peer Review Policy: Double Blind Peer Review
- Review Time: 2-4 Months
- Contact E-mail: igj.journal@gmail.com
Articles in Press
Current Issue
Vol 6, No 4 (2023); in press
Original Article
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Objective: L-carnitine deficiency causes various pathological conditions such as muscle weakness and erythropoietin-resistant anemia in hemodialysis patients. The present study was conducted to compare the therapeutic effect of erythropoietin alone and with the combination of L-carnitine on anemia in hemodialysis patients.
Materials and methods: In this clinical trial study, 24 hemodialysis patients were admitted to the dialysis department of Imam Ali Hospital in 2019. Eligible patients were divided into two equal groups of treatment with erythropoietin alone and the combination of L-carnitine and erythropoietin. A complete blood count (CBC) sample was taken from the patients and the hemoglobin level was measured before and after the treatment.
Results: The mean age of the patients in the erythropoietin treatment group and erythropoietin and L-carnitine combination treatment group was 18.66 ± 3.70 and 23.83 ± 5.70 years, respectively, and a significant difference was observed between the two groups (P=0.015). There was no significant difference between the two groups in the amount of hemoglobin before the treatment (P=0.327). The mean hemoglobin of hemodialysis patients after treatment, in the group treated with erythropoietin and the group receiving erythropoietin with L-carnitine, were 9.8±1.6 and 10.6±3.9 g/dL, respectively, and there was no significant difference between the two groups in terms of hemoglobulin (P=0.324).
Conclusion: Our results showed that receiving erythropoietin alone and erythropoietin together with L-carnitine did not have a significant effect in improving blood parameters in patients with anemia undergoing hemodialysis.
Case Report
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It has been established that Recombinase Activating Genes (RAG1 and RAG2) mutations are responsible for classic T-B-NK+ severe combined immunodeficiency (SCID). On the other hand, it has now become evident that certain mutations within these genes can also lead to other forms of combined immunodeficiency, antibody deficiency, and even autoimmunity.
In this report, we present a case involving a 9-month-old female patient who presents with clinical and laboratory findings indicative of systemic lupus erythematosus (SLE). Following the diagnosis of early-onset SLE and considering the presence of concurrent infections, it was considered necessary to investigate potential underlying monogenic disorders associated with inborn errors of immunity. Immunological evaluations demonstrated a combined immunodeficiency and whole exome sequencing confirmed that the patient has a mutation in the RAG1 gene.
