Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 2 1 2019 03 01 1 21 Hassan Abolhassani Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden Marzieh Tavakol Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Zahra Chavoshzadeh Pediatric Infections Research Center, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Seyed Alireza Mahdaviani Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Tooba Momen Department of Allergy and Clinical Immunology, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran Reza Yazdani Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran Gholamreza Azizi Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran Masoud Movahedi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Amir Ali Hamidieh Hematology, Oncology and Stem Cell Transplantation Research Centre, Tehran University of Medical Sciences, Tehran, Iran Nasrin Behniafard Department of Allergy and Clinical Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mohammad Nabavi Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Saba Arshi Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Mohammad Hassan Bemanian Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Morteza Fallahpour Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Sima Shokri Department of Allergy and Clinical Immunology, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. Rasol Molatefi Department of Pediatrics, Bo-Ali children's Hospital of Ardabil University of Medical Sciences, Ardabil, Iran Roya Sherkat Acquired Immunodeficiency Research Center, lsfahan University of Medical Sciences, Isfahan, lran Afshin Shirkani Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran Reza Amin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Soheila Aleyasin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Reza Faridhosseini Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Farahzad Jabbari-Azad Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Iraj Mohammadzadeh Noncommunicable Pediatric Diseases Research Center, Amirkola Hospital, Babol University of Medical Sciences, Babol, Iran Javad Ghaffari Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran Alireza Shafiei Department of Immunology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran Arash Kalantari Department of Immunology and Allergy, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Mahboubeh Mansouri Immunology and Allergy Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran Mehrnaz Mesdaghi Immunology and Allergy Department, Mofid Children's Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran Delara Babaie Pediatric Infections Research Center, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hamid Ahanchian Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Khoshkhui Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Habib Soheili Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran Mohammad Hossein Eslamian Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Taher Cheraghi Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran Abbas Dabbaghzadeh Noncommunicable Pediatric Diseases Research Center, Amirkola Hospital, Babol University of Medical Sciences, Babol, Iran Mahmoud Tavassoli Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Rasoul Nasiri Kalmarzi Cellular & Molecular Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Seyed Hamidreza Mortazavi Department of Pediatrics, Kermanshah University of Medical Sciences, Kermanshah, Iran Sara Kashef Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Hossein Esmaeilzadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Javad Tafaroji Department of Pediatrics, Qom University of Medical Sciences, Qom, Iran Abbas Khalili Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Fariborz Zandieh Department of Immunology, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran Mahnaz Sadeghi-Shabestari Department of Immunology and Allergy, Tabriz University of Medical Sciences, Tabriz, Iran Sepideh Darougar Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Fatemeh Behmanesh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Hedayat Akbari Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mohammadreza Zandkarimi Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Farhad Abolnezhadian Department of Immunology and Allergy, Ahvaz University of Medical Sciences, Ahvaz, Iran Abbas Fayezi Department of Immunology and Allergy, Ahvaz University of Medical Sciences, Ahvaz, Iran Mojgan Moghtaderi Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Akefeh Ahmadiafshar Mousavi Hospital, Zanjan University of Meical Sciences, Zanjan, Iran Behzad Shakerian Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Vahid Sajedi Department of Immunology and Allergy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Behrang Taghvaei Department of Immunology and Allergy, Semnan University of Medical Sciences, Semnan, Iran Mojgan Safari Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Marzieh Heidarzadeh Department of Immunology and Allergy, Kashan University of Medical Sciences, Kashan, Iran Babak Ghalehbaghi Department of Pediatrics, 17th Shahrivar Children's Hospital, Guilan University of Medical Sciences, Rasht, Iran Seyed Mohammad Fathi Department of Immunology and Allergy, Qazvin University of Medical Sciences, Qazvin, Iran Behzad Darabi Department of Immunology and Allergy, Ilam University of Medical Sciences, Ilam, Iran Saeed Bazregari Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran Nasrin Bazargan Department of Immunology and Allergy, Kerman University of Medical Sciences, Kerman, Iran Alireza Khayatzadeh Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran Naser Javahertrash Department of Allergy and Clinical Immunology, Rasool e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Bahram Bashardoust Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammadali Zamani Department of Immunology and Allergy, Shahrekord University of Medical Sciences, Shahrekord , Iran Azam Mohsenzadeh Department of Pediatrics, Lorestan University of Medical Sciences, Khorramabad, Iran Sarehsadat Ebrahimi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Samin Sharafian Allergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr, Iran Ahmad Vosughimotlagh Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Mitra Tafakoridelbari Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Maziar Rahimi Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Parisa Ashournia Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Anahita Razaghian Division of Allergy and Clinical Immunology, Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran, University of Medical Sciences, Tehran, Iran Fatemeh Aghaeimeybodi Department of Internal Medicine Shahid Sadoughi University of Medical Sciences, Yazd, Iran Setareh Mamishi Pediatric Infectious Diseases Research Center, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran Nima Parvaneh Iranian Primary Immunodeficiencies Network (IPIN), Tehran University of Medical Science, Tehran, Iran Nima Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran Asghar Aghamohammadi Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran, and the University of Medical Science, Tehran, Iran 2019 01 19 Primary immunodeficiency (PID) is a group of more than 400 distinct genetic disorders affecting both children and adults. As signs and symptoms of PID are usually heterogeneous and unspecific, diagnosis and follow-up of these patients can be challenging based on the available human resources and laboratory facilities. In order to reach a distinct national protocol and due to little evidence to guide appropriate or universal guidelines to improve the current status of management of the disease, the Iranian PID network designed a consensus appropriate for regional resources. This review summarizes this PID guideline based on the importance of different clinical complications and the level of medical authority visiting those at the first line. Moreover, for each complication, appropriate interventions for improving approach are mentioned. https://igj.tums.ac.ir/index.php/igj/article/view/9 https://igj.tums.ac.ir/index.php/igj/article/download/9/11