Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 3 4 2020 12 01 180 186 Soheila Alyasin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Kanannejad Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Hossein Esmaeilzadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Hesamedin Nabavizadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Reza Amin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran 2021 07 17 Asthma is one of the most common respiratory diseases caused by chronic airway inflammation. A complex network of cytokines could affect asthma development.IL-4, IL-13, IL-17, and IL-33 have been identified as cytokines associated with asthma severity and these cytokines can be considered as candidate biomarkers for predicting the asthma severity while the IL-10 is lower in asthmatics compared with healthy subjects. There are many controversies about the IL-22, IL-25, and TGF-β levels between the Iranian publications. No significant differences have been observed between the healthy subjects and the asthmatic cases regarding the IL-6 and IL-8 levels. https://igj.tums.ac.ir/index.php/igj/article/view/77 https://igj.tums.ac.ir/index.php/igj/article/download/77/54