Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 8 3 2025 03 12 273 287 Fatemeh Tajik Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran; Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran Sara Kamali Zonouzi Tehran University of Medical Sciences Sepideh Razi Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran 2025 03 02 2025 03 12 Pancreatic cancer is still one of the most lethal malignancies across the world, and hence exploring new biomarkers related to the progression and invasive nature of this cancer is important to overcome its resistance to various types of treatments through the design of new therapeutic strategies. Several markers have been shown to play a role in pancreatic cancer invasion, but CA19-9, CA125, and noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, are the most common ones. In the current review, the role of these markers in pancreatic cancer progression, invasion, and metastasis, as well as related mechanisms, has been provided, and their potential to be utilized in pancreatic cancer diagnosis and treatment has been discussed. https://igj.tums.ac.ir/index.php/igj/article/view/201 https://igj.tums.ac.ir/index.php/igj/article/download/201/187