Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 7 3 2024 09 22 137 149 Tahereh Soltantoye Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Marziyeh Samiee Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Ghanbar Mahmoodi Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran 2025 02 16 2025 02 16 Currently, the novel coronavirus disease (COVID-19) is one of the global challenges that remains inadequately addressed and is not being treated effectively. It is essential to acknowledge the role of supplements in strengthening the immune system to reduce the risk of infection. Food provides a well-established source of adequate macronutrients and micronutrients, all essential for the proper functioning of the immune system. Among the micronutrients, vitamins A, C, D, E, and B play crucial roles in the immune system's effective response to infections. This study explores the role of vitamins in the immune system and their impact on defense against COVID-19. https://igj.tums.ac.ir/index.php/igj/article/view/180 https://igj.tums.ac.ir/index.php/igj/article/download/180/152