Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 7 3 2024 09 22 99 116 Sina Moghaddam Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran Mina Sheikh School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Amin Khazeei Tabari Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran; USERN Office, Mazandaran University of Medical Sciences, Sari, Iran Pouya Darzi Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran; USERN Office, Mazandaran University of Medical Sciences, Sari, Iran Milad Rafiaei Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; USERN Office, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Mahdieh Sheikh USERN Office, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Food Science and Technology, College of Agriculture, Isfahan University of Technology, Isfahan, Iran 2025 02 16 2025 02 16 The development of COVID-19 vaccines with high efficacy has given people hope to overcome the pandemic. However, the increasing number of reports of side effects could affect the number of people who are adherent to vaccination. In most cases, pain, fever, and fatigue have been reported, which is the normal side effect of many vaccines. More serious side effects have also been reported, such as Guillain-Barre syndrome, thrombotic thrombocytopenia, anaphylaxis, and death. Although these side effects seem to be lethal, they are rare, and vaccination is the most efficient strategy to overcome this disease. https://igj.tums.ac.ir/index.php/igj/article/view/178 https://igj.tums.ac.ir/index.php/igj/article/download/178/151