Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 7 1 2024 03 22 24 29 Shirin Mohamadi Division of Neonatology, Department of Pediatrics, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Shiva Mohammadi Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran Maliheh Kadivar Department of Pediatrics, Division of Neonatology, School of Medicine, Tehran University of Medical Sciences, Children’s Medical Center, Tehran, Iran 2024 12 27 2024 12 27 Physiological jaundice of the newborn is a complex benign disease that rarely persists in the second week of life. Neonatal cholestasis (NC) is caused by a disorder in the formation of bile by liver cells or obstruction of the flow of bile through the intrahepatic or extrahepatic biliary tree, which leads to the accumulation of bile substances in the liver, blood, and extrahepatic tissues. This state may continue until the first six months of infancy, and its vulnerability to other cholestatic agents increases. This fact makes NC an uncommon feature of neonatal liver disease rather than a late manifestation. The aim of this paper is to review the definitions, etiologies, clinical manifestations, treatment, and management strategies for NC infants. https://igj.tums.ac.ir/index.php/igj/article/view/162 https://igj.tums.ac.ir/index.php/igj/article/download/162/138