Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 5 4 2022 12 22 149 153 Sahar Barzamini Department of Pediatrics, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Roohollah Barzamini Department of Electrical Engineering, Central Tehran, Islamic Azad University, Tehran, Iran. Naeeme Taslimi Taleghani Department of Pediatrics, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran 2023 02 28 2023 02 28 Objective: Pre-eclampsia (preE) is pregnancy-induced hypertension affecting a significant proportion of pregnant women worldwide and can cause detrimental effects on the mother and newborn. Recognition of contributing factors of health in neonates with pre-eclamptic mothers is important to reduce the burden of the problem. The aim of the study was to determine the hematologic and coagulation factors in term and preterm neonates born to mothers with pre-eclampsia. Method and Materials: In this observational cross-sectional comparative study, 104 neonates born to mothers with pre-eclampsia in Imam-Hossein Hospital from 2018 to 2021 were enrolled. The neonates were divided into term and preterm groups according to the gestational age of the mothers. Maternal and fetal parameters of neonates were collected. The hematologic and coagulation factors were recorded and compared. Results: The finding of the study demonstrated that the mean leukocyte ( P=0.030), hemoglobin ( P=0.0001), and platelet ( P=0.0001) were significantly higher in term neonates. The mean PT ( P=0.003), PPT ( P=0.001), and INR ( P=0.003) were significantly higher in preterm cases. Conclusion: Totally, according to the obtained results it may be concluded that CBC indexes and coagulopathy in term and preterm neonates born to mothers with pre-eclampsia are significantly different. https://igj.tums.ac.ir/index.php/igj/article/view/126 https://igj.tums.ac.ir/index.php/igj/article/download/126/112