Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 6 1 2023 03 22 6 20 Soroush Najdaghi Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Sepideh Razi Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran Amene Saghazadeh Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran 2023 01 04 2023 02 28 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), is a pandemic crisis. Little is known about the treatment of this disease, and supportive care is the only therapy for patients with COVID-19. It has been shown that mineral vitamins have an important role in improving the health status of the patients, and several studies have investigated their effects on patients affected with other coronaviruses. In this review, the probable mechanisms of action of each vitamin against COVID-19 infection, the benefits of co-therapy of vitamins with other supplements, and the recommended daily intake of each nutrient are discussed. https://igj.tums.ac.ir/index.php/igj/article/view/119 https://igj.tums.ac.ir/index.php/igj/article/download/119/115