Tehran University of Medical Sciences Immunology and Genetics Journal 2645-4831 5 1 2022 03 22 1 19 EN Amirhossein Rismanbaf Cellular and molecular undergraduate student, Faculty of Modern Sciences, Islamic Azad University of Medical Sciences, Tehran, Iran 2022 08 29 2022 12 12 Cancer is one of the main causes of death all over the world, accounting for about 10 million deaths in 2020. On the other hand, a lot of money, time and energy are spent in the treatment process of this disease. In fact, cancer is a big challenge that we have been facing for years, but there is still no method that can definitively cure this disease. For years, we have mainly used surgery, chemotherapy and radiation therapy to treat cancer. Although many advances have been made in these methods, these methods are not a definitive cure for all types of cancer and also have many complications and impose high costs on patients. By the high success of Chimeric Antigen Receptor (CAR) T cell therapy in the treatment of leukemia, hopes for effective treatment for various types of cancer increased, but by testing this method in solid tumors, it was found that this method has low efficiency in solid tumors. In this review article, I consider the challenges and mechanisms that cancer cells apply to resist different main therapies, and finally, by comparing the challenges of different therapies, I conclude that virus therapy has a higher potential than other methods to end the problem of cancer and become a definitive cure for cancer. https://igj.tums.ac.ir/index.php/igj/article/view/101 https://igj.tums.ac.ir/index.php/igj/article/download/101/90