Original Article

Cardiac Complications in Patients with Common Variable Immune Deficiency: A Longitudinal Study


Background: The common variable immune deficiency (CVID) is known as the most prevalent symptomatic primary immune deficiency (PID) diseases, which is characterized by hypogammaglobulinemia with variable infectious and noninfectious manifestations. In this study, the researchers aimed to evaluate the frequency of cardiac disorders and investigate its association with other manifestations in CVID patients.
Method: A total of 337 CVID patients registered in the Iranian Primary Immunodeficiency Registry were evaluated in this study. The questionnaire was completed for all patients to collect the participants’ demographic data, clinical manifestations and laboratory finding. The analysis was performed between the two groups of the study including CVID patients with cardiac manifestation and those without it.
Results: The prevalence rate of cardiac manifestation was calculated to be 9.1%. pericardial and myocardial diseases and pulmonary hypertension were the most prevalent complications. CVID patients with a history of cardiac problem had significantly higher prevalence rates of otitis media, lymphoproliferative disorders, splenomegaly, hepatomegaly, failure to thrive and lower numbers of CD8+ T cells and CD19+ B cells compared to the patients without cardiac disorders. Notably, no significant differences were observed in immunoglobulins serum levels, CD3+ and CD4+ T cells between the patients with and without cardiac manifestation.
Conclusion: Regular echocardiographic evaluation and of CVID patients for cardiac complications especially for inflammatory cardiac disease, heart failure and pulmonary hypertension, is critical to reduce the risk of heart disease.

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IssueVol 4, No 2 (2021) QRcode
SectionOriginal Article
DOI https://doi.org/10.18502/igj.v4i2.9984
Common Variable Immune Deficiency Cardiac Disorders Clinical Manifestations Autoimmunity Pericardial Disease

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How to Cite
Ramzi N, Yazdani S, Talakoob H, Rasouli SE, Karim H, Azizi G. Cardiac Complications in Patients with Common Variable Immune Deficiency: A Longitudinal Study. Immunol Genet J. 2021;4(2):87-94.