Autoimmunity and Fibromyalgia: Common Pathogenesis and Promising Biomarkers

Abstract

Fibromyalgia(FM) is a common rheumatologic syndrome with a wide spectrum of symptoms that can be debilitating. In spite of attempts to discover FM pathogenesis, It is still challenging and poorly understood, and there is no reliable biomarker for the diagnosis of FM. Recent studies showed the role of the immune system in the pathogenesis of FM. So, this review focuses on the immunological aspects of FM pathogenesis, including associated autoimmune comorbidities, autoantibodies, and inflammatory cytokines.