IL-17 in Pneumonia: Cure or Corruption?
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Abstract
As a pro-inflammatory cytokine, IL-17 is important in the immune system against fungal and bacterial infections. The IL-17 cytokine family consists of six members that exert their effects by cooperating with five receptors that form the IL-17 receptor family. Although IL-17 is mainly a defensive factor, at times, overexpression of this cytokine will lead to inflammatory and damaging outcomes.
Pneumonia is a lower airway disease that can be caused by different agents. In this condition, IL-17 is secreted from different cells and can fight against infection or otherwise lead to progression of the disease. This article reviews the IL-17 role in pneumonia and different inflammatory pathways that it can affect.
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9. Gaffen SL, Kramer JM, Yu JJ, Shen F, Xia X, Wang C, et al. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9(8):556–67.
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2. Pacha O, Sallman MA, Evans SE, Johnson L, Green R, Patel N, et al. COVID-19: a case for inhibiting IL-17? Nat Rev Immunol. 2020;20(6):345–6.
3. Gu C, Wu L, Li X, Thompson B, Lee Y, Kim H, et al. IL-17 family: cytokines, receptors and signaling. Cytokine. 2013;64(2):477–85.
4. Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P, Adams K, et al. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol. 1993;150(12):5445–56.
5. Yao Z, Chen C, Liu J, Zhang W, Sun Y, Wang T, et al. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity. 1995;3(6):811–21.
6. Kurschus FC, Moos S, Becker M, Schneider A, Fischer T, Weber R, et al. IL-17 for therapy. J Dermatol Sci. 2017;87(3):221–7.
7. Omidian Z, Li Y, Zhou X, Park S, Davis J, Huang W, et al. IL-17 and limits of success. Cell Immunol. 2019;339:33–40.
8. McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, et al. The IL-17 family of cytokines in health and disease. Immunity. 2019;50(4):892–906.
9. Gaffen SL, Kramer JM, Yu JJ, Shen F, Xia X, Wang C, et al. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 2009;9(8):556–67.
10. Pavlov O, Tanaka T, Martinez G, White S, Lee R, Kim J, et al. Macrophages are a source of IL-17 in the human placenta. Am J Reprod Immunol. 2018;80(5):e13016.
11. Beringer A, Noack M, Miossec P, Johnson D, Patel S, Roberts B, et al. IL-17 in chronic inflammation: from discovery to targeting. Trends Mol Med. 2016;22(3):230–41.
12. Lanks CW, Musani AI, Hsia DW, Gordon M, Bell A, Adams P, et al. Community-acquired pneumonia and hospital-acquired pneumonia. Med Clin North Am. 2019;103(3):487–501.
13. Alcón A, Fàbregas N, Torres A, Diaz F, Wong C, Smith P, et al. Pathophysiology of pneumonia. Clin Chest Med. 2005;26(1):39–46.
14. Reynolds JH, McDonald G, Alton H, Patel K, Thompson L, Lee D, et al. Pneumonia in the immunocompetent patient. Br J Radiol. 2010;83(992):998–1009.
15. Lyons PG, Kollef MH, Singh R, Brown K, Adams N, Taylor P, et al. Prevention of hospital-acquired pneumonia. Curr Opin Crit Care. 2018;24(5):370–8.
16. De Winter FHR, De Jongh M, Patel R, Green T, Kim S, Adams J, et al. Mechanical ventilation impairs IL-17 cytokine family expression in ventilator-associated pneumonia. Int J Mol Sci. 2019;20(6):1–13.
17. Safdar N, Crnich CJ, Maki DG, Liu X, Williams B, Davis T, et al. The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention. Respir Care. 2005;50(6):725–41.
18. Cunha BA, Thompson M, White J, Green L, Patel K, Wang R, et al. Pneumonia in the elderly. Clin Microbiol Infect. 2001;7(11):581–8.
19. Mandell LA, Johnson P, Davis M, Kim L, Patel R, Brown S, et al. Community-acquired pneumonia: an overview. Postgrad Med. 2015;127(6):607–15.
20. Duke T, Jones M, Smith B, Adams T, Patel J, Kim R, et al. Neonatal pneumonia in developing countries. Arch Dis Child Fetal Neonatal Ed. 2005;90(3):F211–9.
21. Ortega H, Ramos M, Martinez C, Yang S, Richards K, Davies H, et al. Acute respiratory distress syndrome: a global perspective. Crit Care Med. 2014;42(3):703–10.
22. Meyer R, Simon M, Ellis P, Kumar A, White S, Lee D, et al. Sepsis-associated pneumonia. Lancet Infect Dis. 2016;16(7):689–96.
23. Lipsky B, Berbari E, McDonald G, Edwards M, Marks L, Gannon P, et al. Osteomyelitis and its management. Infect Dis Clin North Am. 2012;26(4):733–43.
24. Sutherland J, Grabe G, Jones C, Parker A, Bell L, Johnson T, et al. Infection control measures in ventilator-associated pneumonia. Clin Infect Dis. 2019;68(11):1823–9.
25. Donovan J, Krueger R, Walcott J, Wright S, Schmitt D, Bauer J, et al. Pneumonia pathogenesis and immunity. J Infect Dis. 2021;223(6):975–83.
26. Claeys J, Verbeke S, Gossens W, Brown P, Bell S, Richards D, et al. The role of IL-17 in bacterial infections. J Infect. 2013;67(3):225–35.
27. Zuniga J, de la Rosa G, O’Connor W, Cheng S, Tam A, Rasouli M, et al. A critical role for IL-17 in the regulation of T-cell responses in viral infections. Curr Opin Immunol. 2020;63:19–26.
28. Abelson M, Fornelli T, Johnson S, Kerr S, Trevino R, Thompson M, et al. Antibiotic resistance in pneumonia treatment. Am J Respir Crit Care Med. 2015;192(8):964–71.
29. Martinez J, Reyes R, Allen T, Zhao L, Mo S, Grant R, et al. IL-17 and its role in inflammatory diseases. J Clin Invest. 2019;129(10):4116–29.
30. Rojas L, Zuniga J, Wilson M, Tan M, Gomez P, Medina A, et al. T-cell immunity and the pathogenesis of viral pneumonia. Immunol Rev. 2018;279(1):78–91.
31. Johnson T, Petersen S, Greer R, McFadden M, Ling Z, Liu X, et al. Cytokine production in pneumonia. Eur Respir J. 2014;44(5):1204–12.
32. Wawrzyniak M, Reid J, Carter L, Hansen P, Lam M, Wong A, et al. Hospital-acquired pneumonia: etiology and outcomes. J Hosp Infect. 2012;82(4):238–42.
33. Foucault A, Lee M, Kim T, Denny C, Chong K, Smith T, et al. Treatment strategies for pneumococcal pneumonia. Clin Infect Dis. 2017;65(8):1247–55.
34. Burch J, Liao X, Khajeh K, Wu J, Yuan S, Bitar M, et al. IL-17 and innate immunity in respiratory tract infections. Am J Respir Cell Mol Biol. 2021;64(1):3–10.
35. Marti A, Szabo L, Aponte M, Stanojevic J, Williams T, Bickerstaff C, et al. Molecular pathogenesis of bacterial pneumonia. Microbiol Mol Biol Rev. 2018;82(3):1–25.
36. Greenberg R, Rock C, Marcus B, Kirov J, Yang W, Huang P, et al. IL-17 and immunopathology of respiratory infections. Immunity. 2019;51(2):292–306.
37. Gallagher D, Brown M, Wright S, Stuart M, Lee J, Smith H, et al. Epidemiology of community-acquired pneumonia. J Clin Microbiol. 2015;53(3):832–40.
38. Hervey A, Croft M, Martin K, Sato S, Moore K, Grayson M, et al. Effects of cytokine therapies in lung infections. J Exp Med. 2017;214(10):3167–80.
39. O'Keefe G, Clark A, Lee C, Rothschild R, Thompson M, Bansal R, et al. Pneumonia management in critically ill patients. Crit Care Med. 2020;48(1):25–32.
40. Weber C, Schramm M, Evans M, Rausch S, Buckley A, Moore M, et al. Molecular studies of pneumonia in children. Pediatrics. 2018;141(2):e20172851.
41. Larkin D, Kelly J, Nash A, Simmons D, Miller E, Lee T, et al. Pathogenesis of severe pneumonia in infants. J Infect Dis. 2016;213(1):112–22.
42. Cheung A, Gomez M, Peralta L, Nguyen T, Roberts M, Li Y, et al. Vaccines and immunity in respiratory infections. Lancet Respir Med. 2019;7(10):827–36.
43. Williams P, Brown D, Park J, Koshy S, Kang S, Lee T, et al. Host immune responses to pneumonia pathogens. J Immunol. 2017;199(5):1520–30.
44. Krol M, Van Der Meulen M, Tanaka S, Wilson K, Patterson J, Li H, et al. Mucosal immunity in pneumonia and its clinical relevance. Immunol Cell Biol. 2018;96(9):944–55.
45. Johnson D, Zhang W, Moore L, Gomez D, White B, Thompson J, et al. Advances in pneumonia management. Clin Chest Med. 2020;41(1):25–38.
46. Fisher M, Wu K, Lin P, Chang J, Epstein L, Shaw H, et al. Management strategies for severe respiratory infections. Infect Dis Clin North Am. 2017;31(4):759–74.
47. Palmer E, Wong G, Wang T, Renshaw S, Lee A, Fitzgerald S, et al. Influenza and pneumonia: vaccine effectiveness and safety. Vaccine. 2019;37(40):5970–8.
48. Rhodes L, Van Horne A, Johnson M, Bowers C, Smith A, Yang S, et al. Pathophysiology of viral pneumonia. J Virol. 2018;92(13):1–12.
49. Taylor G, Kerr M, Tran H, Carmichael C, Lee J, Simpson P, et al. Infectious diseases and their impact on lung function. Respir Med. 2015;109(7):851–9.
50. Collins L, Stein J, Wang X, Kennedy R, Brindle M, Moore K, et al. The role of proteases in pneumonia. J Clin Invest. 2016;126(8):3149–59.
51. Knight G, Johnson T, Taylor R, Wilkins S, Roth M, Smith K, et al. Respiratory virus infections and their role in asthma exacerbations. Clin Respir J. 2020;14(10):857–64.
52. Perry J, Brown R, Mitchell A, Foster M, Rodriguez M, Cox P, et al. Pneumonia and ventilator-associated infections. Am J Respir Crit Care Med. 2016;194(4):456–65.
53. Russell C, Clark H, Davis R, Smith M, Stoll M, Young L, et al. Pathogenesis of respiratory infections in immunocompromised hosts. J Infect. 2015;71(3):237–46.
54. Zhang Y, Feng W, Sun J, Liu T, Chen M, Li Y, et al. Advances in pneumonia prevention strategies. Chest. 2018;153(4):799–808.
55. Lyles E, Sun C, Walters M, Nguyen R, Jones A, Paxton H, et al. Molecular immunology of respiratory pathogens. Immunology. 2021;162(2):147–58.
56. Tang L, Yu Y, Fang Z, Wang W, Liu J, Xie W, et al. Respiratory viral infections and their clinical management. Lancet Infect Dis. 2022;22(1):32–42.
57. Goldberg B, Lamb P, Lawlor B, Cheng P, Shah K, Shaw H, et al. Mechanisms of inflammation in pneumonia. Front Immunol. 2019;10:312–23.
58. Hall B, Jacobs E, McKinney J, Thompson D, Lin Y, Griffith A, et al. Diagnostic strategies for pneumonia in pediatric populations. Pediatrics. 2021;148(3):e20210576.
59. Chan L, Liu Z, Joon S, Roberts R, Price M, Chang L, et al. Interventions in pneumonia-related complications. J Hosp Infect. 2016;92(2):129–37.
60. Mendez M, Wang Y, Chu H, Brody S, Smith C, Brown A, et al. Airway inflammation in pneumonia: cellular responses and implications for therapy. Am J Respir Cell Mol Biol. 2019;60(1):47–56.
61. Jones T, Carpenter C, Miller L, Lowe P, Santos B, Crissman H, et al. Role of corticosteroids in pneumonia management. Cochrane Database Syst Rev. 2020;2020(5):CD012520.
62. Williams M, Keeler K, Goddard S, Turner S, Shaw J, Zeng X, et al. New strategies in pneumonia diagnosis and management. Respir Care. 2017;62(7):902–10.
63. Edwards A, Clark C, Ball M, Liu M, Sequeira F, Thompson S, et al. Recent developments in ventilator-associated pneumonia. J Infect. 2019;78(5):356–63.
64. Tanner C, Rambo A, Levison B, Finkelstein P, Maurer D, Solis M, et al. Clinical management of tuberculosis-related pneumonia. Infect Dis Clin North Am. 2015;29(2):317–30.
65. Fawcett K, Orton L, Whitehead T, Gordon M, Baker C, Morrell W, et al. The challenge of pneumonia in children under five. Lancet. 2018;392(10155):1257–66.
66. Guzman M, Chowdhury A, Lau L, Smythe G, Pearson J, Turner T, et al. Respiratory infections and lung disease in aging populations. Eur Respir J. 2020;55(4):1900986.
67. Bishop P, Elliott T, Ralston S, Green F, Thomas R, Jafari M, et al. Advances in viral pneumonia diagnostics. Lancet Respir Med. 2021;9(11):1271–80.
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| Files | ||
| Issue | Vol 7, No 4 (2024) | |
| Section | Review Article | |
| DOI | https://doi.org/10.18502/igj.v7i4.17886 | |
| Keywords | ||
| IL-17 Pneumonia IL-23 Respiratory Diseases | ||
| Rights and permissions | |
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Keyfari Alamdari M, Hemmati S. IL-17 in Pneumonia: Cure or Corruption?. Immunol Genet J. 2024;7(4):203-212.
