Impact of Herbal Medicine and Probiotics in Pediatric Asthma
-
Yasamin Fatemeh Sadat Zojaji
,
Nafiseh Erfanian
,
Yazdan Ebrahimpour
,
Sahbasadat Khatami
,
Rana Tafrishi
,
Hamid Ahanchian
Abstract
Asthma, a prevalent chronic condition in children, poses significant challenges in management. While conventional treatments like inhaled corticosteroids and beta-agonists are standard, there is increasing interest in the role of herbal medicine and probiotics as complementary therapies. This paper reviews the impact of herbal remedies—such as Butterbur, Ginger, Turmeric, Boswellia, Licorice, and Ephedra—and probiotics on pediatric asthma. Evidence suggests these therapies may reduce inflammation and improve respiratory function, potentially benefiting asthma management. However, variability in product quality and study designs necessitates further research. Future studies should focus on validating these interventions through rigorous clinical trials to better integrate herbal medicine and probiotics into comprehensive asthma care for children.
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2. Field T, Henteleff T, Hernandez-Reif M, Martinez E, Mavunda K, Kuhn C, et al. Children with asthma have improved pulmonary functions after massage therapy. The Journal of Pediatrics. 1998;132(5):854-58.
3. George MTopaz M. A Systematic Review of Complementary and Alternative Medicine for Asthma Self-management. Nursing Clinics of North America. 2013;48(1):53-149.
4. Ahanchian H, Jones CM, Chen Y-sSly PD. Respiratory viral infections in children with asthma: do they matter and can we prevent them? BMC Pediatrics. 2012;12(1):147.
5. Kudo M, Ishigatsubo YAoki I. Pathology of asthma. Front Microbiol. 2013;4:263.
6. Lai CK, Beasley R, Crane J, Foliaki S, Shah JWeiland S. Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax. 2009;64(6):476-83.
7. Wen M-C, Wei C-H, Hu Z-Q, Srivastava K, Ko J, Xi S-T, et al. Efficacy and tolerability of antiasthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. Journal of Allergy and Clinical Immunology. 2005;116(3):517-24.
8. Boing AC, Ribeiro Santiago PH, Tesser CD, Furlan IL, Bertoldi ADBoing AF. Prevalence and associated factors with integrative and complementary practices use in Brazil. Complementary Therapies in Clinical Practice. 2019;37:1-5.
9. Shen JOraka E. Complementary and alternative medicine (CAM) use among children with current asthma. Preventive Medicine. 2012;54(1):27-31.
10. Amaral-Machado L, Oliveira WN, Moreira-Oliveira SS, Pereira DT, Alencar EN, Tsapis N, et al. Use of natural products in asthma treatment. Evidence‐Based Complementary and Alternative Medicine. 2020;2020(1):1021258.
11. Matyja D, Abod L, Ilnicka N, Sadlik MZuziak P. Pharmacology and non-pharmacology treatment in a way of well controlled childhood asthma. Journal of Education, Health and Sport. 2023;13(4):249-55.
12. Lucas S, Kumar DS, Leach DMJPhillips DAC. Complementary and alternative medicine use in Australian children with acute respiratory tract infection - A cross-sectional survey of parents. Complementary Therapies in Clinical Practice. 2020;39:101171.
13. Kouzegaran S, Ahanchian H, Emami SA, Ansari N, Yousefi J, Moazzen N, et al. Herbal remedies used by asthmatic children in Iran. Reviews in Clinical Medicine. 2023;10(1):26-32.
14. Javid A, Motevalli Haghi N, Emami SA, Ansari A, Zojaji SA, Khoshkhui M, et al. Short-course administration of a traditional herbal mixture ameliorates asthma symptoms of the common cold in children. Avicenna J Phytomed. 2019;9(2):126-33.
15. Fujimura KELynch SV. Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe. 2015;17(5):592-602.
16. Kirjavainen PV, Karvonen AM, Adams RI, Täubel M, Roponen M, Tuoresmäki P, et al. Farm-like indoor microbiota in non-farm homes protects children from asthma development. Nat Med. 2019;25(7):1089-95.
17. Kozik AHuang YJ. Ecological interactions in asthma: from environment to microbiota and immune responses. Curr Opin Pulm Med. 2020;26(1):27-32.
18. Karvonen AM, Kirjavainen PV, Täubel M, Jayaprakash B, Adams RI, Sordillo JE, et al. Indoor bacterial microbiota and development of asthma by 10.5 years of age. J Allergy Clin Immunol. 2019;144(5):1402-10.
19. Ahanchian H, Jafari SA, Ansari E, Ganji T, Kiani MA, Khalesi M, et al. A multi-strain Synbiotic may reduce viral respiratory infections in asthmatic children: a randomized controlled trial. Electron Physician. 2016;8(9):2833-39.
20. Derakhshan A, Sadeghi M, Dehghani M, Salari R, Khadem-Rezaiyan M, Mirsadraee M, et al. Efficacy of Herbal Medicines on Lung Function in Asthma: a systematic review and meta-analysis of randomized controlled trials. Journal of pharmacopuncture. 2023;26(2):124.
21. Chaddha VGupta R. Potential applications of medicinal plants in symptomatic treatment of asthma: A review. Biomedicine. 2023;43(01):259-64.
22. Danesch U. Petasites hybridus (Butterbur root) extract in the treatment of asthma-an open trial. Alternative Medicine Review. 2004;9(1):54-62.
23. Mihajilov-Krstev T, Jovanović B, Zlatković B, Matejić J, Vitorović J, Cvetković V, et al. Phytochemistry, toxicology and therapeutic value of Petasites hybridus subsp. ochroleucus (common butterbur) from the Balkans. Plants. 2020;9(6):700.
24. Kleeberg-Hartmann J, Vogler BMesslinger K. Petasin and isopetasin reduce CGRP release from trigeminal afferents indicating an inhibitory effect on TRPA1 and TRPV1 receptor channels. The Journal of Headache and Pain. 2021;22(1):23.
25. Lee DK, Haggart K, Robb FMLipworth BJ. Butterbur, a herbal remedy, confers complementary anti-inflammatory activity in asthmatic patients receiving inhaled corticosteroids. Clin Exp Allergy. 2004;34(1):110-4.
26. Lee KP, Kang S, Noh MS, Park SJ, Kim JM, Chung HY, et al. Therapeutic effects of s-petasin on disease models of asthma and peritonitis. Biomol Ther (Seoul). 2015;23(1):45-52.
27. Shih CH, Huang TJ, Chen CM, Lin YLKo WC. S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. Evid Based Complement Alternat Med. 2011;2011:132374.
28. Mashabela MNOtang-Mbeng W. The therapeutic and phytopharmacological potential of ginger (Zingiber officinale). Ginger-Cultivation and Use: IntechOpen; 2023.
29. Gumbarewicz E, Jarząb A, Stepulak AKukula-Koch W. Zingiber officinale Rosc. in the treatment of metabolic syndrome disorders—A Review of In Vivo Studies. International Journal of Molecular Sciences. 2022;23(24):15545.
30. Mao Q-Q, Xu X-Y, Cao S-Y, Gan R-Y, Corke H, Beta T, et al. Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods. 2019;8(6):185.
31. Townsend EA, Siviski ME, Zhang Y, Xu C, Hoonjan BEmala CW. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol. 2013;48(2):157-63.
32. Kardan M, Rafiei A, Ghaffari J, Valadan R, Morsaljahan ZHaj-ghorbani ST. Effect of ginger extract on expression of GATA3, T-bet and ROR-γt in peripheral blood mononuclear cells of patients with Allergic Asthma. Allergologia et Immunopathologia. 2019;47(4):378-85.
33. Kim E, Jang S, Yi JK, Kim H, Kwon HJ, Im H, et al. Ginger‑derived compounds exert in vivo and in vitro anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response. Experimental and Therapeutic Medicine. 2022;23(1):1-11.
34. Babu AK, Rosdi NA, Tan CS, Menon BVPaneerselvam GS. Curcumin and Tulsi For Pulmonary Disorders In Pandemic Century. Progress in Drug Discovery & Biomedical Science. 2023;6(1).
35. Park JY, Chu GE, Park S, Park C, Aryal S, Kang WJ, et al. Therapeutic efficacy of curcumin enhanced by microscale discoidal polymeric particles in a murine asthma model. Pharmaceutics. 2020;12(8):739.
36. Naufal MA, Triastari SKShalihah RH. Unrooting the Potential of Intranasal Administration of Curcumin as a Novel Asthma Controller by Alleviating Airway Inflammation. Journal of Asian Medical Students' Association. 2021;9(1).
37. Ghiamati Yazdi F, Zakeri A, Ark Iv, Leusink-Muis T, Braber S, Soleimanian-Zad S, et al. Crude Turmeric Extract Improves the Suppressive Effects of Lactobacillus rhamnosus GG on Allergic Inflammation in a Murine Model of House Dust Mite-Induced Asthma. Frontiers in Immunology. 2020;11.
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| Files | ||
| Issue | Vol 7, No 1 (2024) | |
| Section | Review Article | |
| DOI | https://doi.org/10.18502/igj.v7i1.17515 | |
| Keywords | ||
| Herbal remedies Probiotics Asthma Respiratory Disorder | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Zojaji YFS, Erfanian N, Ebrahimpour Y, Khatami S, Tafrishi R, Ahanchian H. Impact of Herbal Medicine and Probiotics in Pediatric Asthma. Immunol Genet J. 2024;7(1):1-10.
