Genetics of aberrant immune responses during tumor progression among Iranian population

Abstract

Immune system has a critical tumor suppressor function via detection and elimination of the tumor cells. Tumor cells immune escaping is commonly observed during neoplastic transformations. Immune response suppression or aberrations facilitate immune escape that promotes tumor progression in distant or primary locations via epithelial-mesenchymal transition and angiogenesis, respectively. It has been reported that there is a rising trend of cancer incidence among Iranian population. Since, aberrant immune responses are involved in tumorigenesis; immunotherapeutic methods can be efficient for the tumor cells elimination. In the present review, we discussed all of the immune related genes that have been associated with tumor progression among Iranian population to clarify the genetics of immune deficiency during tumor progression in this population. T regulatory and T helper related genes were the most frequent deregulated genes during tumor progression in Iranian population. This review paves the way to suggest an immune specific panel of genetic markers for diagnostic and immunotherapeutic purposes among Iranian cancer patients.